InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cx3cl1

Summary

InnateDB Protein

IDBP-182618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cx3cl1

Protein Name

chemokine (C-X3-C motif) ligand 1

Synonyms

AB030188; ABCD-3; AI848747; CX3C; Cxc3; D8Bwg0439e; Scyd1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034230

InnateDB Gene

IDBG-182616 (Cx3cl1)

Protein Structure

UniProt Annotation

Function

The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (By similarity). Binds to CX3CR1. {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.Processed fractalkine: Secreted.

Disease Associations

Tissue Specificity

Highest levels in brain. Lower levels in kidney, heart and lung. Also found in skeletal muscle and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0019221	cytokine-mediated signaling pathway
GO:0030593	neutrophil chemotaxis
GO:0032914	positive regulation of transforming growth factor beta1 production
GO:0042060	wound healing
GO:0045766	positive regulation of angiogenesis
GO:0048246	macrophage chemotaxis
GO:0048247	lymphocyte chemotaxis
GO:0050729	positive regulation of inflammatory response
GO:0051041	positive regulation of calcium-independent cell-cell adhesion
GO:0060055	angiogenesis involved in wound healing
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand