InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc47a1

Summary

InnateDB Protein

IDBP-182633.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc47a1

Protein Name

solute carrier family 47, member 1

Synonyms

1300013J15Rik; AI036982; MATE1; mMATE1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000010267

InnateDB Gene

IDBG-182631 (Slc47a1)

Protein Structure

UniProt Annotation

Function

Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16330770, ECO:0000269PubMed:16641166, ECO:0000269PubMed:17715386}; Multi- pass membrane protein {ECO:0000269PubMed:16330770, ECO:0000269PubMed:16641166, ECO:0000269PubMed:17715386}. Note=Predominantly localized to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver).

Disease Associations

Tissue Specificity

Predominantly expressed in kidney and liver. Also expressed in various cells, including brain glia-like cells and capillaries, pancreatic duct cells, urinary bladder epithelium, adrenal gland cortex, heart, stomach, small intestine, thyroid gland, testes, alpha cells of the islets of Langerhans, Leydig cells, and vitamin A-storing Ito cells. Expressed in heart, stomach, small intestine, bladder, thyroid gland, adrenal gland and testes (at protein level). {ECO:0000269PubMed:16330770}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005451	monovalent cation:hydrogen antiporter activity
GO:0015238	drug transmembrane transporter activity
GO:0015297	antiporter activity

Biological Process

GO:0006855	drug transmembrane transport
GO:0015695	organic cation transport
GO:0015893	drug transport
GO:0055085	transmembrane transport
GO:1902600	hydrogen ion transmembrane transport