Version 5.4
Homo sapiens Protein: SERPINA9
Summary
InnateDB Protein IDBP-18268.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINA9
Protein Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000298845
InnateDB Gene IDBG-18262 (SERPINA9)
Protein Structure
UniProt Annotation
Function Protease inhibitor that inhibits trypsin and trypsin- like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro). {ECO:0000269PubMed:17447896}.
Subcellular Localization Isoform 1: Secreted.Isoform 2: Cytoplasm {ECO:0000305}.Isoform 3: Cytoplasm {ECO:0000305}.Isoform 4: Cytoplasm {ECO:0000305}.Isoform 5: Cytoplasm {ECO:0000305}.Isoform 6: Cytoplasm {ECO:0000305}.Isoform 7: Membrane {ECO:0000305}; Single- pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies. {ECO:0000269PubMed:12819018, ECO:0000269PubMed:17447896, ECO:0000269PubMed:17898315, ECO:0000269PubMed:18550480}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86WD7
PhosphoSite PhosphoSite-Q86WD7
TrEMBL
UniProt Splice Variant
Entrez Gene 327657
UniGene Hs.317970
RefSeq NP_001035983
HUGO HGNC:15995
OMIM 615677
CCDS CCDS41983
HPRD 11546
IMGT
EMBL AK301082 AL132708 AY185496 AY185497 AY220118 AY220119 AY220120 AY220121 AY358700 BC111498
GenPept AAI11499 AAO32345 AAO32346 AAO65242 AAO65243 AAO65244 AAO65245 AAQ89063 BAG62686

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca