InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lipc

Summary

InnateDB Protein

IDBP-182687.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lipc

Protein Name

lipase, hepatic

Synonyms

AI256194; HL; Hpl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034731

InnateDB Gene

IDBG-182685 (Lipc)

Protein Structure

UniProt Annotation

Function

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004806	triglyceride lipase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0016298	lipase activity

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0008203	cholesterol metabolic process
GO:0019433	triglyceride catabolic process
GO:0030301	cholesterol transport
GO:0034372	very-low-density lipoprotein particle remodeling
GO:0034374	low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0042632	cholesterol homeostasis
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005615	extracellular space
GO:0034364	high-density lipoprotein particle

Protein Structure and Domains

PDB ID

MGI:96216

InterPro

IPR000734 Lipase
IPR001024 PLAT/LH2 domain
IPR002333 Hepatic lipase
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein lipase, LIPH
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF01477
PF00151

PRINTS

PR00821
PR00824

PIRSF

PIRSF000865

SMART

SM00308

TIGRFAMs

Post-translational Modifications

Modification

Cross-References