InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lin7b

Summary

InnateDB Protein

IDBP-182742.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lin7b

Protein Name

lin-7 homolog B (C. elegans)

Synonyms

LIN-7B; MALS-2; Veli2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003971

InnateDB Gene

IDBG-182740 (Lin7b)

Protein Structure

UniProt Annotation

Function

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface. {ECO:0000269PubMed:15317815}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15494546}; Peripheral membrane protein {ECO:0000269PubMed:15494546}. Basolateral cell membrane {ECO:0000269PubMed:15494546}; Peripheral membrane protein {ECO:0000269PubMed:15494546}. Cell junction {ECO:0000269PubMed:15494546}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269PubMed:15494546}; Peripheral membrane protein {ECO:0000269PubMed:15494546}. Cell junction, tight junction {ECO:0000269PubMed:15494546}. Cell junction, synapse, synaptosome {ECO:0000269PubMed:15494546}. Note=Enriched in synaptosomes and at epithelial cell-cell junctions. Mainly basolateral in renal epithelial cells.

Disease Associations

Tissue Specificity

Expressed in the kidney; predominantly in the vasa recta. {ECO:0000269PubMed:11742811, ECO:0000269PubMed:15494546}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006887	exocytosis
GO:0007269	neurotransmitter secretion
GO:0015031	protein transport

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0014069	postsynaptic density
GO:0016323	basolateral plasma membrane
GO:0043005	neuron projection
GO:0045202	synapse
GO:0045211	postsynaptic membrane