InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ascl1

Summary

InnateDB Protein

IDBP-182851.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ascl1

Protein Name

achaete-scute complex homolog 1 (Drosophila)

Synonyms

AI225900; ASH1; bHLHa46; Mash1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020243

InnateDB Gene

IDBG-182849 (Ascl1)

Protein Structure

UniProt Annotation

Function

Transcription factor that controls transcriptional expression of its target genes by binding to the E box (5'-CANNTG- 3'). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Essential for the generation of olfactory and autonomic neurons. {ECO:0000269PubMed:10648228, ECO:0000269PubMed:16020526, ECO:0000269PubMed:17728344, ECO:0000269PubMed:8217843}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Developing CNS and PNS at embryonic and post- natal stages. {ECO:0000269PubMed:16020526, ECO:0000269PubMed:8217843, ECO:0000269PubMed:8424959}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0001764	neuron migration
GO:0003358	noradrenergic neuron development
GO:0003359	noradrenergic neuron fate commitment
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0007346	regulation of mitotic cell cycle
GO:0007389	pattern specification process
GO:0007399	nervous system development
GO:0007400	neuroblast fate determination
GO:0007405	neuroblast proliferation
GO:0008593	regulation of Notch signaling pathway
GO:0010001	glial cell differentiation
GO:0010226	response to lithium ion
GO:0010468	regulation of gene expression
GO:0014003	oligodendrocyte development
GO:0021527	spinal cord association neuron differentiation
GO:0021529	spinal cord oligodendrocyte cell differentiation
GO:0021530	spinal cord oligodendrocyte cell fate specification
GO:0021750	vestibular nucleus development
GO:0021779	oligodendrocyte cell fate commitment
GO:0021879	forebrain neuron differentiation
GO:0021892	cerebral cortex GABAergic interneuron differentiation
GO:0021902	commitment of neuronal cell to specific neuron type in forebrain
GO:0021954	central nervous system neuron development
GO:0021987	cerebral cortex development
GO:0022008	neurogenesis
GO:0030154	cell differentiation
GO:0030182	neuron differentiation
GO:0030856	regulation of epithelial cell differentiation
GO:0032526	response to retinoic acid
GO:0042127	regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045787	positive regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0048484	enteric nervous system development
GO:0048485	sympathetic nervous system development
GO:0048486	parasympathetic nervous system development
GO:0048663	neuron fate commitment
GO:0048665	neuron fate specification
GO:0048666	neuron development
GO:0048699	generation of neurons
GO:0048709	oligodendrocyte differentiation
GO:0050767	regulation of neurogenesis
GO:0050769	positive regulation of neurogenesis
GO:0050883	musculoskeletal movement, spinal reflex action
GO:0051593	response to folic acid
GO:0060163	subpallium neuron fate commitment
GO:0060165	regulation of timing of subpallium neuron differentiation
GO:0060166	olfactory pit development
GO:0060579	ventral spinal cord interneuron fate commitment
GO:0061100	lung neuroendocrine cell differentiation
GO:0061102	stomach neuroendocrine cell differentiation
GO:0061103	carotid body glomus cell differentiation
GO:0061104	adrenal chromaffin cell differentiation
GO:0061549	sympathetic ganglion development
GO:0070849	response to epidermal growth factor
GO:0071259	cellular response to magnetism
GO:2000179	positive regulation of neural precursor cell proliferation