InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pask

Summary

InnateDB Protein

IDBP-182893.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pask

Protein Name

PAS domain containing serine/threonine kinase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027493

InnateDB Gene

IDBG-182891 (Pask)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation. {ECO:0000269PubMed:15148392, ECO:0000269PubMed:17878307, ECO:0000269PubMed:18509100, ECO:0000269PubMed:21181396}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Strongly up-regulated in postmeiotic germ cells during spermatogenesis. {ECO:0000269PubMed:12972598}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0043576	regulation of respiratory gaseous exchange
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0046777	protein autophosphorylation
GO:0070092	regulation of glucagon secretion
GO:2000505	regulation of energy homeostasis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Protein Structure and Domains

PDB ID

MGI:2155936

InterPro

IPR000014 PAS domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR013767 PAS fold
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF13188
PF13426
PF00069
PF07714
PF00989

PRINTS

PR00109

PIRSF

SMART

SM00091
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt