InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Igf1

Summary

InnateDB Protein

IDBP-182957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Igf1

Protein Name

insulin-like growth factor 1

Synonyms

C730016P09Rik; Igf-1; Igf-I;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093005

InnateDB Gene

IDBG-182955 (Igf1)

Protein Structure

UniProt Annotation

Function

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005159	insulin-like growth factor receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0001775	cell activation
GO:0001932	regulation of protein phosphorylation
GO:0001974	blood vessel remodeling
GO:0007399	nervous system development
GO:0007623	circadian rhythm
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010001	glial cell differentiation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0021940	positive regulation of cerebellar granule cell precursor proliferation
GO:0030104	water homeostasis
GO:0030324	lung development
GO:0030879	mammary gland development
GO:0031017	exocrine pancreas development
GO:0032878	regulation of establishment or maintenance of cell polarity
GO:0035264	multicellular organism growth
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046326	positive regulation of glucose import
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0048286	lung alveolus development
GO:0048468	cell development
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048839	inner ear development
GO:0050650	chondroitin sulfate proteoglycan biosynthetic process
GO:0051246	regulation of protein metabolic process
GO:0051897	positive regulation of protein kinase B signaling
GO:0060426	lung vasculature development
GO:0060463	lung lobe morphogenesis
GO:0060509	Type I pneumocyte differentiation
GO:0060510	Type II pneumocyte differentiation
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736	prostate gland growth
GO:0060740	prostate gland epithelium morphogenesis
GO:0060741	prostate gland stromal morphogenesis
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2000288	positive regulation of myoblast proliferation