InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sec31a

Summary

InnateDB Protein

IDBP-183029.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sec31a

Protein Name

Sec31 homolog A (S. cerevisiae)

Synonyms

1810024J13Rik; ABP125; ABP130; AU042160; HSPC275; Sec31l1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092157

InnateDB Gene

IDBG-183023 (Sec31a)

Protein Structure

UniProt Annotation

Function

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associates with membranes in a GTP- dependent manner. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0051592	response to calcium ion

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0030120	vesicle coat
GO:0030134	ER to Golgi transport vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070971	endoplasmic reticulum exit site