Version 5.4
Homo sapiens Protein: HTRA4
Summary
InnateDB Protein IDBP-18303.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTRA4
Protein Name HtrA serine peptidase 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000305919
InnateDB Gene IDBG-18301 (HTRA4)
Protein Structure
UniProt Annotation
Function Serine protease. {ECO:0000305}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006508 proteolysis
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001478 PDZ domain
IPR001940 Peptidase S1C
IPR002350 Kazal domain
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PF00595
PF13180
PF00050
PF07648
PRINTS PR00834
PIRSF
SMART SM00020
SM00228
SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P83105
PhosphoSite PhosphoSite-P83105
TrEMBL B4DTF7
UniProt Splice Variant
Entrez Gene 203100
UniGene Hs.661014
RefSeq NP_710159
HUGO HGNC:26909
OMIM 610700
CCDS CCDS6110
HPRD 08818
IMGT
EMBL AC108863 AK075205 AK300197 BC057765
GenPept AAH57765 BAC11470 BAG61969

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca