Version 5.4
| Mus musculus Protein: Pcdh8 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||
| InnateDB Protein | IDBP-183102.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | Pcdh8 | ||||||||||||
| Protein Name | protocadherin 8 | ||||||||||||
| Synonyms | 1700080P15Rik; Papc; | ||||||||||||
| Species | Mus musculus | ||||||||||||
| Ensembl Protein | ENSMUSP00000045333 | ||||||||||||
| InnateDB Gene | IDBG-183100 (Pcdh8) | ||||||||||||
| Protein Structure |
|
||||||||||||
| UniProt Annotation | |||||||||||||
| Function | Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway (By similarity). In hippocampal neurons, may play a role in the down- regulation of dendritic spines, maybe through its action on CDH2 endocytosis. {ECO:0000250, ECO:0000269PubMed:17988630}. | ||||||||||||
| Subcellular Localization | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Note=Expressed in neuronal cell bodies and dendrites. Localized to excitatory, but not with inhibitory, synapses. {ECO:0000250}. | ||||||||||||
| Disease Associations | |||||||||||||
| Tissue Specificity | |||||||||||||
| Comments | |||||||||||||
| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
||||||||||||
| Gene Ontology | |||||||||||||
Molecular Function |
|
||||||||||||
| Biological Process |
|
||||||||||||
| Cellular Component |
|
||||||||||||
| Protein Structure and Domains | |||||||||||||
| PDB ID | MGI:1306800 | ||||||||||||
| InterPro |
IPR002126
Cadherin IPR013164 Cadherin, N-terminal IPR015919 Cadherin-like |
||||||||||||
| PFAM |
PF00028
PF08266 |
||||||||||||
| PRINTS |
PR00205
|
||||||||||||
| PIRSF | |||||||||||||
| SMART |
SM00112
|
||||||||||||
| TIGRFAMs | |||||||||||||
| Post-translational Modifications | |||||||||||||
| Modification | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | Q7TSK3 | ||||||||||||
| PhosphoSite | PhosphoSite-Q7TSK3 | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 18530 | ||||||||||||
| UniGene | |||||||||||||
| RefSeq | NP_067518 | ||||||||||||
| MGI ID | |||||||||||||
| MGI Symbol | Pcdh8 | ||||||||||||
| OMIM | |||||||||||||
| CCDS | CCDS27303 | ||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | AF231125 AK048638 BC052388 BC053008 CH466535 | ||||||||||||
| GenPept | AAF63319 AAH52388 AAH53008 BAC33404 EDL35755 | ||||||||||||