Version 5.4
Mus musculus Protein: Parpbp
Summary
InnateDB Protein IDBP-183108.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Parpbp
Protein Name RIKEN cDNA 4930547N16 gene
Synonyms 4930547N16Rik; AI503644; PARI;
Species Mus musculus
Ensembl Protein ENSMUSP00000038375
InnateDB Gene IDBG-183106 (Parpbp)
Protein Structure
UniProt Annotation
Function Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:2000042 negative regulation of double-strand break repair via homologous recombination
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1922567
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6IRT3
PhosphoSite PhosphoSite-Q6IRT3
TrEMBL E9QAI0
UniProt Splice Variant
Entrez Gene 75317
UniGene Mm.179378
RefSeq NP_083525
MGI ID
MGI Symbol Parpbp
OMIM
CCDS CCDS36022
HPRD
IMGT
EMBL AC139754 AC168315 AK030970 AK131981 AK150571 AK151268 AK152208 BC070476
GenPept AAH70476 BAC27197 BAE20920 BAE29666 BAE30255 BAE31036

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca