InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rimkla

Summary

InnateDB Protein

IDBP-183226.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rimkla

Protein Name

ribosomal modification protein rimK-like family member A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058996

InnateDB Gene

IDBG-183224 (Rimkla)

Protein Structure

UniProt Annotation

Function

Catalyzes the synthesis of N-acetyl-L-aspartyl-L- glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate. {ECO:0000269PubMed:20657015, ECO:0000269PubMed:21454531}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in spinal cord and brain. {ECO:0000269PubMed:21454531}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004363	glutathione synthase activity
GO:0005524	ATP binding
GO:0046872	metal ion binding
GO:0072590	N-acetyl-L-aspartate-L-glutamate ligase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0006750	glutathione biosynthetic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:3040686

InterPro

IPR003806 ATP-grasp fold, DUF201-type
IPR004218 Prokaryotic glutathione synthetase, ATP-binding
IPR004666 Ribosomal S6 modification enzyme RimK/Lysine biosynthesis enzyme LysX
IPR011761 ATP-grasp fold
IPR013651 ATP-grasp fold, RimK-type

PFAM

PF02655
PF02955
PF08443

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6PFX8

PhosphoSite