Version 5.4
Mus musculus Protein: Faim2
Summary
InnateDB Protein IDBP-183293.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Faim2
Protein Name Fas apoptotic inhibitory molecule 2
Synonyms 2900002L20Rik; Lfg; Lfg2; NMP25; Nmp35; Tmbim2;
Species Mus musculus
Ensembl Protein ENSMUSP00000023750
InnateDB Gene IDBG-183291 (Faim2)
Protein Structure
UniProt Annotation
Function Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. {ECO:0000269PubMed:17635665, ECO:0000269PubMed:21209208, ECO:0000269PubMed:21957071}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane raft {ECO:0000269PubMed:17635665}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
Disease Associations
Tissue Specificity Brain. Highly expressed in cerebellum, also found in cortex, olfactory bulb, and hippocampus. {ECO:0000269PubMed:17635665, ECO:0000269PubMed:21957071}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0002931 response to ischemia
GO:0006915 apoptotic process
GO:0021549 cerebellum development
GO:0021680 cerebellar Purkinje cell layer development
GO:0021681 cerebellar granular layer development
GO:0021702 cerebellar Purkinje cell differentiation
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045121 membrane raft
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:1919643
InterPro IPR006214 Bax inhibitor 1-related
PFAM PF01027
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K097
PhosphoSite PhosphoSite-Q8K097
TrEMBL
UniProt Splice Variant
Entrez Gene 72393
UniGene Mm.401346
RefSeq NP_082500
MGI ID
MGI Symbol Faim2
OMIM
CCDS CCDS37203
HPRD
IMGT
EMBL AF468028 AK013476 AK030513 AK129246 AK158960 BC032278
GenPept AAH32278 AAM46781 BAB28874 BAC26999 BAC98056 BAE34742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca