InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gnptab

Summary

InnateDB Protein

IDBP-183349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnptab

Protein Name

N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020251

InnateDB Gene

IDBG-183343 (Gnptab)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment (By similarity). {ECO:0000250}.

Subcellular Localization

N-acetylglucosamine-1-phosphotransferase subunit alpha: Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.N-acetylglucosamine-1-phosphotransferase subunit beta: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
GO:0005509	calcium ion binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups