Version 5.4
Mus musculus Protein: Guca2a
Summary
InnateDB Protein IDBP-183352.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Guca2a
Protein Name guanylate cyclase activator 2a (guanylin)
Synonyms Guca2;
Species Mus musculus
Ensembl Protein ENSMUSP00000024015
InnateDB Gene IDBG-183350 (Guca2a)
Protein Structure
UniProt Annotation
Function Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Localized in both crypts and villi in the small intestine and to superficial epithelial cells in the colon.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008047 enzyme activator activity
GO:0030250 guanylate cyclase activator activity
Biological Process
GO:0031284 positive regulation of guanylate cyclase activity
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:102738
InterPro IPR000879 Guanylin
PFAM PF02058
PRINTS PR00774
PIRSF PIRSF001849
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P33680
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 14915
UniGene Mm.2614
RefSeq NP_032216
MGI ID
MGI Symbol Guca2a
OMIM
CCDS CCDS18586
HPRD
IMGT
EMBL AK075814 BC012640 L05516 M95175 U60528
GenPept AAA37715 AAA37758 AAB05758 AAH12640 BAC35981

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca