InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccno

Summary

InnateDB Protein

IDBP-183384.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccno

Protein Name

cyclin O

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040083

InnateDB Gene

IDBG-183382 (Ccno)

Protein Structure

UniProt Annotation

Function

Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking (By similarity). May be involved in apoptosis in lymphoid cells; however, this result requires additional evidences in vivo. May be involed in oocyte meiotic resumption in oocytes. {ECO:0000250, ECO:0000269PubMed:18927588, ECO:0000269PubMed:19609756}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:24747639}. Note=Localizes to the apical part of cytoplasm. {ECO:0000269PubMed:24747639}.

Disease Associations

Tissue Specificity

Present in respiratory cells (at protein level). Highly expressed in oocytes. {ECO:0000269PubMed:19609756, ECO:0000269PubMed:24747639}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004844	uracil DNA N-glycosylase activity
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006284	base-excision repair
GO:0007049	cell cycle
GO:0009790	embryo development
GO:0042493	response to drug
GO:0051301	cell division
GO:0051726	regulation of cell cycle