Version 5.4
Mus musculus Protein: Mcin
Summary
InnateDB Protein IDBP-183399.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mcin
Protein Name predicted gene 6320
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000089721
InnateDB Gene IDBG-183397 (Mcin)
Protein Structure
UniProt Annotation
Function Transcription regulator required for multiciliate cell differentiation. Acts by promoting transcription of genes required for multiciliate cell formation. Probably acts in a multiprotein complex. Plays a role in mitotic cell cycle progression by progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:21543332}. Note=Excluded from the nucleolus. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006275 regulation of DNA replication
GO:0006351 transcription, DNA-templated
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0042384 cilium assembly
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:3648807
InterPro IPR022786 Geminin family
PFAM PF07412
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UZ45
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 622408
UniGene Mm.360976
RefSeq NP_001033003
MGI ID
MGI Symbol Mcidas
OMIM
CCDS CCDS36783
HPRD
IMGT
EMBL AC165265 AK134107 BC150962 CH466568
GenPept AAI50963 BAE22015 EDL18399

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca