Homo sapiens Protein: CLEC12B | |||||
---|---|---|---|---|---|
Summary | |||||
InnateDB Protein | IDBP-18345.6 | ||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
Gene Symbol | CLEC12B | ||||
Protein Name | C-type lectin domain family 12, member B | ||||
Synonyms | |||||
Species | Homo sapiens | ||||
Ensembl Protein | ENSP00000344563 | ||||
InnateDB Gene | IDBG-545208 (CLEC12B) | ||||
Protein Structure | |||||
UniProt Annotation | |||||
Function | Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. {ECO:0000269PubMed:17562706}. | ||||
Subcellular Localization | Cell membrane {ECO:0000269PubMed:17562706}; Single-pass type II membrane protein {ECO:0000269PubMed:17562706}. | ||||
Disease Associations | |||||
Tissue Specificity | Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis. {ECO:0000269PubMed:17562706}. | ||||
Comments | |||||
Interactions | |||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||||
Gene Ontology | |||||
Molecular Function |
|
||||
Biological Process |
|
||||
Cellular Component |
|
||||
Protein Structure and Domains | |||||
PDB ID | |||||
InterPro |
IPR001304
C-type lectin IPR013600 Ly49-like N-terminal IPR016187 C-type lectin fold |
||||
PFAM |
PF00059
PF08391 |
||||
PRINTS | |||||
PIRSF | |||||
SMART |
SM00034
|
||||
TIGRFAMs | |||||
Post-translational Modifications | |||||
Modification | |||||
Cross-References | |||||
SwissProt | Q2HXU8 | ||||
PhosphoSite | PhosphoSite-Q2HXU8 | ||||
TrEMBL | |||||
UniProt Splice Variant | |||||
Entrez Gene | 387837 | ||||
UniGene | Hs.629334 | ||||
RefSeq | NP_001123470 | ||||
HUGO | HGNC:31966 | ||||
OMIM | |||||
CCDS | CCDS44830 | ||||
HPRD | 18266 | ||||
IMGT | |||||
EMBL | AK128243 AY358810 CH471094 DQ368812 | ||||
GenPept | AAQ89170 ABC96323 BAC87350 EAW96136 | ||||