InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gzma

Summary

InnateDB Protein

IDBP-183455.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gzma

Protein Name

granzyme A

Synonyms

AW494114; Ctla-3; Ctla3; Hf; SE1; TSP-1; TSP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023897

InnateDB Gene

IDBG-183453 (Gzma)

Protein Structure

UniProt Annotation

Function

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted. Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes.

Disease Associations

Tissue Specificity

Found in cytotoxic lymphocytes and in normal lymphoid tissues such as thymus and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0019835	cytolysis
GO:0032078	negative regulation of endodeoxyribonuclease activity
GO:0043065	positive regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0051354	negative regulation of oxidoreductase activity
GO:0051603	proteolysis involved in cellular protein catabolic process