InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxo6

Summary

InnateDB Protein

IDBP-183549.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxo6

Protein Name

forkhead box O6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099716

InnateDB Gene

IDBG-183547 (Foxo6)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. {ECO:0000269PubMed:12857750}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12857750}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00089, ECO:0000269PubMed:12857750}. Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors.

Disease Associations

Tissue Specificity

Expressed in brain in areas of the nucleus accumbens, cingulate cortex, parts of the amygdala and in the hippocampus. {ECO:0000269PubMed:12857750}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008301	DNA binding, bending
GO:0019901	protein kinase binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0007389	pattern specification process
GO:0008286	insulin receptor signaling pathway
GO:0009888	tissue development
GO:0042127	regulation of cell proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048513	organ development