InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde1a

Summary

InnateDB Protein

IDBP-183582.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde1a

Protein Name

phosphodiesterase 1A, calmodulin-dependent

Synonyms

AI987702; AW125737;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099714

InnateDB Gene

IDBG-183578 (Pde1a)

Protein Structure

UniProt Annotation

Function

Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516	calmodulin binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0034391	regulation of smooth muscle cell apoptotic process
GO:0046069	cGMP catabolic process
GO:0048660	regulation of smooth muscle cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:1201792

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR013706 3\'5\'-cyclic nucleotide phosphodiesterase N-terminal
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233
PF08499

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt