InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klhl1

Summary

InnateDB Protein

IDBP-183613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klhl1

Protein Name

kelch-like 1 (Drosophila)

Synonyms

mKIAA1490;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022666

InnateDB Gene

IDBG-183611 (Klhl1)

Protein Structure

UniProt Annotation

Function

May play a role in organizing the actin cytoskeleton of the brain cells.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Highly expressed in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0007626	locomotory behavior
GO:0007628	adult walking behavior
GO:0016358	dendrite development
GO:0021680	cerebellar Purkinje cell layer development

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0030425	dendrite
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:2136335

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JI74