InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Accn2

Summary

InnateDB Protein

IDBP-183647.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Accn2

Protein Name

amiloride-sensitive cation channel 2, neuronal

Synonyms

Accn2; AI843610; ASIC; ASIC1a; B530003N02Rik; BNaC2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023758

InnateDB Gene

IDBG-183645 (Accn2)

Protein Structure

UniProt Annotation

Function

Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. {ECO:0000269PubMed:11988176, ECO:0000269PubMed:12843249, ECO:0000269PubMed:15369669, ECO:0000269PubMed:15578512, ECO:0000269PubMed:17060608, ECO:0000269PubMed:17662962}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4. {ECO:0000269PubMed:11988176}.

Disease Associations

Tissue Specificity

Expressed in brain areas receiving strong excitatory corticofugal input. In hippocampus, expressed in the hilus of the dentate gyrus. In the cerebral cortex expressed in anterior and posterior cingulate cortex, sensory and motor cortices. In the sensory cortex strongest expression is detected in the whisker barrel field. In sensorimotor and cingulate cortex expression is elevated in layer III. Also expressed in basal ganglia, striatum, ventral pallidum, olfactory tubercle, and nucleus accumbens. Weakly expressed in thalamus with the exception of the habenula and the medial septal nuclei. In olfactory bulb, preferentially expressed in the glomerular layer, within glomeruli. Expressed in cerebellum in the molecular and granule cell layers. Strongly expressed in amygdala complex, particularly in the lateral and basolateral nuclei. Isoform 1 is more abundant in brain compared to isoform 2 (at protein level). Expressed in the nodose ganglion and dorsal root ganglion. Expressed in dendritic spine cells. {ECO:0000269PubMed:11988176, ECO:0000269PubMed:12843249, ECO:0000269PubMed:15578512}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005261	cation channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity
GO:0022839	ion gated channel activity
GO:0044736	acid-sensing ion channel activity

Biological Process

GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0007613	memory
GO:0008306	associative learning
GO:0010447	response to acidity
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0046929	negative regulation of neurotransmitter secretion
GO:0050915	sensory perception of sour taste
GO:0070207	protein homotrimerization
GO:0070588	calcium ion transmembrane transport
GO:0071467	cellular response to pH