InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dach1

Summary

InnateDB Protein

IDBP-183692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dach1

Protein Name

dachshund 1 (Drosophila)

Synonyms

Dac; Dach;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064970

InnateDB Gene

IDBG-183688 (Dach1)

Protein Structure

UniProt Annotation

Function

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1 (By similarity). Binds to chromatin DNA via its DACHbox-N domain. {ECO:0000250, ECO:0000269PubMed:12130660, ECO:0000269PubMed:12215533, ECO:0000269PubMed:14628042}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at higher levels in adult kidney and lung, and at lower levels in brain and testis. Expressed in embryonal kidneys, eyes, cochleae and limb buds. {ECO:0000269PubMed:10502110, ECO:0000269PubMed:11543628}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001075	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001967	suckling behavior
GO:0006355	regulation of transcription, DNA-templated
GO:0007585	respiratory gaseous exchange
GO:0008283	cell proliferation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0030336	negative regulation of cell migration
GO:0046545	development of primary female sexual characteristics
GO:0048147	negative regulation of fibroblast proliferation
GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly
GO:0060244	negative regulation of cell proliferation involved in contact inhibition