InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mmp15

Summary

InnateDB Protein

IDBP-183733.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp15

Protein Name

matrix metallopeptidase 15

Synonyms

AI503551; MT2-MMP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034243

InnateDB Gene

IDBG-183731 (Mmp15)

Protein Structure

UniProt Annotation

Function

Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0032355	response to estradiol

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:109320

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A
IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal

PFAM

PF00413
PF01471
PF00045
PF11857

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References