InnateDB Protein
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IDBP-183736.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Smarcd1
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Protein Name
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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
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Synonyms
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AA407987; Baf60a; D15Kz1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000023759
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InnateDB Gene
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IDBG-183734 (Smarcd1)
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Protein Structure
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Function |
Involved in chromatin remodeling. Has a strong influence on the Vitamin D-mediated transcriptional activity from an enhancer Vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. {ECO:0000250, ECO:0000269PubMed:17640523}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:2725507, ECO:0000269PubMed:8804307}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
78 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1933623
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InterPro |
IPR003121
SWIB/MDM2 domain
IPR019835
SWIB domain
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PFAM |
PF02201
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PRINTS |
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PIRSF |
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SMART |
SM00151
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TIGRFAMs |
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Modification |
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SwissProt |
Q61466
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PhosphoSite |
PhosphoSite-Q61466
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
83797
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UniGene |
Mm.273756
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RefSeq |
NP_114030
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MGI ID |
1UHR
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MGI Symbol |
Smarcd1
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OMIM |
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CCDS |
CCDS37204
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HPRD |
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IMGT |
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EMBL |
AK075611
BC026783
BC059921
M25773
U66620
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GenPept |
AAA53377
AAC52794
AAH26783
BAC35856
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