InnateDB Protein
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IDBP-183751.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Il17ra
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Protein Name
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interleukin 17 receptor A
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Synonyms
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AW538159; Cdw217; Il17r; VDw217;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000002976
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InnateDB Gene
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IDBG-183749 (Il17ra)
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Protein Structure
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Function |
Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:21993848}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
|
Protein-Protein |
10
[view]
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Protein-DNA |
9
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
GO:0032747
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positive regulation of interleukin-23 production
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GO:0071345
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cellular response to cytokine stimulus
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GO:0072537
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fibroblast activation
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GO:1900017
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positive regulation of cytokine production involved in inflammatory response
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Cellular Component |
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PDB ID |
MGI:107399
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InterPro |
IPR013568
SEFIR
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PFAM |
PF08357
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q60943
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PhosphoSite |
PhosphoSite-Q60943
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
16172
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UniGene |
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RefSeq |
NP_032385
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MGI ID |
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MGI Symbol |
Il17ra
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OMIM |
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CCDS |
CCDS20482
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HPRD |
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IMGT |
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EMBL |
U31993
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GenPept |
AAC52357
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