InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spic

Summary

InnateDB Protein

IDBP-183754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spic

Protein Name

Spi-C transcription factor (Spi-1/PU.1 related)

Synonyms

AU019198; C76795; Prf; Spi-C;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004473

InnateDB Gene

IDBG-183752 (Spic)

Protein Structure

UniProt Annotation

Function

Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression. {ECO:0000269PubMed:19037245}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in lymphoid tissues, including spleen, bone marrow and thymus. According to PubMed:19037245, highly expressed in red pulp macrophages and, at lower, levels in B-cells, but not in other cells, including, monocytes, dendritic cells and other tissue macrophages. According to PubMed:10464163 expressed in pre- and mature B-cells but not in immature B-cells; according to PubMed:10187812 not expressed in pre- but predominantly in mature B-cells and at lower levels in macrophages. {ECO:0000269PubMed:10187812, ECO:0000269PubMed:10464163, ECO:0000269PubMed:19037245}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001824	blastocyst development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter