InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VKORC1L1

Summary

InnateDB Protein

IDBP-18376.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VKORC1L1

Protein Name

vitamin K epoxide reductase complex, subunit 1-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000353998

InnateDB Gene

IDBG-18374 (VKORC1L1)

Protein Structure

UniProt Annotation

Function

Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins. {ECO:0000269PubMed:21367861, ECO:0000269PubMed:23928358, ECO:0000269PubMed:24532791}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:21367861, ECO:0000269PubMed:24532791}; Multi- pass membrane protein {ECO:0000269PubMed:21367861, ECO:0000269PubMed:24532791}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0048038	quinone binding

Biological Process

GO:0017187	peptidyl-glutamic acid carboxylation
GO:0034599	cellular response to oxidative stress
GO:0042373	vitamin K metabolic process
GO:0055114	oxidation-reduction process