InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Frzb

Summary

InnateDB Protein

IDBP-183777.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Frzb

Protein Name

frizzled-related protein

Synonyms

frezzled; fritz; Frp; frzb-1; Sfrp3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028389

InnateDB Gene

IDBG-183775 (Frzb)

Protein Structure

UniProt Annotation

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in kidney, brain, testis. Weak expression in spleen and heart. {ECO:0000269PubMed:9096311, ECO:0000269PubMed:9178261}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0008406	gonad development
GO:0010721	negative regulation of cell development
GO:0014033	neural crest cell differentiation
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030308	negative regulation of cell growth
GO:0042472	inner ear morphogenesis
GO:0043065	positive regulation of apoptotic process
GO:0045600	positive regulation of fat cell differentiation
GO:0060029	convergent extension involved in organogenesis
GO:0060056	mammary gland involution
GO:0061037	negative regulation of cartilage development
GO:0061053	somite development
GO:0070367	negative regulation of hepatocyte differentiation
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090103	cochlea morphogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:892032

InterPro

IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled domain

PFAM

PF01759
PF01392

PRINTS

PIRSF

SMART

SM00643
SM00063

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97401