InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgf21

Summary

InnateDB Protein

IDBP-183780.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgf21

Protein Name

fibroblast growth factor 21

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033099

InnateDB Gene

IDBG-183778 (Fgf21)

Protein Structure

UniProt Annotation

Function

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB. {ECO:0000269PubMed:15902306}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Most abundantly expressed in the liver, also expressed in the thymus at lower levels. {ECO:0000269PubMed:10858549}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0046326	positive regulation of glucose import
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway