InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cited4

Summary

InnateDB Protein

IDBP-183814.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cited4

Protein Name

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4

Synonyms

MRG-2; Mrg2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092408

InnateDB Gene

IDBG-183812 (Cited4)

Protein Structure

UniProt Annotation

Function

Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. {ECO:0000269PubMed:11581164, ECO:0000269PubMed:12504852}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250UniProtKB:Q96RK1}.

Disease Associations

Tissue Specificity

Strongly expressed in heart, spleen and testis, and weakly in liver and kidney. {ECO:0000269PubMed:12504852}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043627	response to estrogen
GO:0045893	positive regulation of transcription, DNA-templated