Version 5.4
Mus musculus Protein: Izumo1
Summary
InnateDB Protein IDBP-183834.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Izumo1
Protein Name izumo sperm-egg fusion 1
Synonyms 1700058F15Rik; Izumo;
Species Mus musculus
Ensembl Protein ENSMUSP00000033100
InnateDB Gene IDBG-183832 (Izumo1)
Protein Structure
UniProt Annotation
Function Essential sperm cell-surface protein required for fertilization by acting as a ligand for FOLR4/JUNO receptor on egg. The IZUMO1:FOLR4/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. {ECO:0000269PubMed:15759005, ECO:0000269PubMed:24739963}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction. {ECO:0000269PubMed:15759005, ECO:0000269PubMed:19658160}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007155 cell adhesion
GO:0007338 single fertilization
GO:0007342 fusion of sperm to egg plasma membrane
GO:0035036 sperm-egg recognition
Cellular Component
GO:0001669 acrosomal vesicle
GO:0002080 acrosomal membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1920706
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D9J7
PhosphoSite PhosphoSite-Q9D9J7
TrEMBL
UniProt Splice Variant
Entrez Gene 73456
UniGene Mm.467941
RefSeq NP_001018013
MGI ID
MGI Symbol Izumo1
OMIM
CCDS CCDS21255
HPRD
IMGT
EMBL AB195681 AK006830
GenPept BAB24761 BAD91011

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca