InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rasip1

Summary

InnateDB Protein

IDBP-183860.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasip1

Protein Name

Ras interacting protein 1

Synonyms

1110025D03Rik; 2610025P08Rik; AI853551; Rain;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062429

InnateDB Gene

IDBG-183858 (Rasip1)

Protein Structure

UniProt Annotation

Function

Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in kidney, heart, skeletal muscle, small intestine and lung. {ECO:0000269PubMed:15031288}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017016	Ras GTPase binding

Biological Process

GO:0001525	angiogenesis
GO:0001570	vasculogenesis
GO:0007165	signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0010507	negative regulation of autophagy
GO:0032319	regulation of Rho GTPase activity
GO:0048754	branching morphogenesis of an epithelial tube