InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc5a8

Summary

InnateDB Protein

IDBP-184001.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc5a8

Protein Name

solute carrier family 5 (iodide transporter), member 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020255

InnateDB Gene

IDBG-183999 (Slc5a8)

Protein Structure

UniProt Annotation

Function

Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. {ECO:0000269PubMed:15322102, ECO:0000269PubMed:15651982, ECO:0000269PubMed:15867356, ECO:0000269PubMed:16805814}.

Subcellular Localization

Membrane {ECO:0000269PubMed:17099289, ECO:0000269PubMed:17245649}; Multi-pass membrane protein {ECO:0000269PubMed:17099289, ECO:0000269PubMed:17245649}. Apical cell membrane; Multi-pass membrane protein {ECO:0000269PubMed:17099289, ECO:0000269PubMed:17245649}. Note=Restricted to the apical cell membrane of enterocytes. {ECO:0000269PubMed:17099289, ECO:0000269PubMed:17245649}.

Disease Associations

Tissue Specificity

Expressed in brain, colon, kidney and in the ileum and jejunum of small intestine. In the kidney, expression occurred in the proximal tubule and the loop of Henle, being restricted to tubular epithelial cells in both the cortex and the medulla. In the colon, predominantly expressed in the distal half of the large bowel and in the most terminal ileum. Localized selectively in the luminal surface of crypts in the large intestine and to the brush border in the middle parts of crypts in the cecum. In the brain, expression was seen throughout, exclusively in neurons, including the cortex, hippocampus, cerebellum and pituitary gland (at protein level). Expression is reduced in oligodendrogliomas. {ECO:0000269PubMed:15322102, ECO:0000269PubMed:15867356, ECO:0000269PubMed:16805814, ECO:0000269PubMed:17099289, ECO:0000269PubMed:17245649}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function