InnateDB Protein
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IDBP-184060.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ndrg4
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Protein Name
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N-myc downstream regulated gene 4
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000036226
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InnateDB Gene
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IDBG-184058 (Ndrg4)
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Protein Structure
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Function |
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor- induced ERK1 and ERK2 phosphorylation. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. {ECO:0000269PubMed:21636852}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in the brain (at protein level). Detected in neurons of various parts of brain, including the olfactory bulb, olfactory tuberculum, cerebral cortex, striatum, hippocampus, dentate gyrus, thalamus, hypothalamus, mesencephalon, cerebellum, pons and medulla oblongata. {ECO:0000269PubMed:21636852}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2384590
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InterPro |
IPR004142
NDRG
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF03096
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BTG7
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PhosphoSite |
PhosphoSite-Q8BTG7
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TrEMBL |
E0CZ50
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UniProt Splice Variant |
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Entrez Gene |
234593
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UniGene |
Mm.394553
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RefSeq |
XP_006530930
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MGI ID |
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MGI Symbol |
Ndrg4
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC113951
AK090374
AK129305
AK168873
BC006595
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GenPept |
AAH06595
BAC41189
BAC98115
BAE40691
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