Version 5.4
Mus musculus Protein: Smap2
Summary
InnateDB Protein IDBP-184141.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smap2
Protein Name stromal membrane-associated GTPase-activating protein 2
Synonyms 1810031K02Rik; AA408614; Smap1l;
Species Mus musculus
Ensembl Protein ENSMUSP00000035800
InnateDB Gene IDBG-184139 (Smap2)
Protein Structure
UniProt Annotation
Function GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network. {ECO:0000269PubMed:16571680}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16571680}. Note=Detected in multiple foci throughout the cytoplasm and in juxtanuclear structures.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1917030
InterPro IPR001164 Arf GTPase activating protein
PFAM PF01412
PRINTS PR00405
PIRSF
SMART SM00105
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TN29
PhosphoSite PhosphoSite-Q7TN29
TrEMBL Q3UM96
UniProt Splice Variant
Entrez Gene 69780
UniGene Mm.407998
RefSeq NP_598477
MGI ID
MGI Symbol Smap2
OMIM
CCDS CCDS18598
HPRD
IMGT
EMBL AK145042 AK152757 BC052413
GenPept AAH52413 BAE26202 BAE31472

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca