Version 5.4
Mus musculus Protein: Pdcd1
Summary
InnateDB Protein IDBP-184150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdcd1
Protein Name programmed cell death 1
Synonyms Ly101; PD-1; Pdc1;
Species Mus musculus
Ensembl Protein ENSMUSP00000027507
InnateDB Gene IDBG-184148 (Pdcd1)
Protein Structure
UniProt Annotation
Function Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Thymus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0006915 apoptotic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:104879
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q02242
PhosphoSite PhosphoSite-Q02242
TrEMBL Q544F3
UniProt Splice Variant
Entrez Gene 18566
UniGene Mm.5024
RefSeq NP_032824
MGI ID 3SBW
MGI Symbol Pdcd1
OMIM
CCDS CCDS15200
HPRD
IMGT
EMBL AK039828 BC119179 BC120602 CH466520 X67914
GenPept AAI19180 AAI20603 BAC30463 CAA48113 EDL39922

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca