InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klf5

Summary

InnateDB Protein

IDBP-184156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klf5

Protein Name

Kruppel-like factor 5

Synonyms

4930520J07Rik; Bteb2; CKLF; IKLF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005279

InnateDB Gene

IDBG-184154 (Klf5)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highest expression in digestive track.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0030033	microvillus assembly
GO:0032534	regulation of microvillus assembly
GO:0035914	skeletal muscle cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060576	intestinal epithelial cell development
GO:0071407	cellular response to organic cyclic compound
GO:1901653	cellular response to peptide

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0043231	intracellular membrane-bounded organelle