InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nr1h4

Summary

InnateDB Protein

IDBP-184283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr1h4

Protein Name

nuclear receptor subfamily 1, group H, member 4

Synonyms

AI957360; Fxr; HRR1; RIP14; Rxrip14;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053092

InnateDB Gene

IDBG-184281 (Nr1h4)

Protein Structure

UniProt Annotation

Function

Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed specifically in liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004872	receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004887	thyroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0032052	bile acid binding
GO:0038181	bile acid receptor activity
GO:0042277	peptide binding
GO:0043565	sequence-specific DNA binding
GO:0046965	retinoid X receptor binding
GO:1902122	chenodeoxycholic acid binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001080	nitrogen catabolite activation of transcription from RNA polymerase II promoter
GO:0006109	regulation of carbohydrate metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008206	bile acid metabolic process
GO:0009749	response to glucose
GO:0030522	intracellular receptor signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0034255	regulation of urea metabolic process
GO:0038185	intracellular bile acid receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048565	digestive tract development
GO:0070858	negative regulation of bile acid biosynthetic process
GO:0071229	cellular response to acid
GO:0071417	cellular response to organonitrogen compound
GO:2000213	positive regulation of glutamate metabolic process
GO:2001250	positive regulation of ammonia assimilation cycle

Cellular Component

GO:0005634	nucleus
GO:0005719	nuclear euchromatin

Protein Structure and Domains

PDB ID

MGI:1352464

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR003069 Ecdysteroid receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR00546
PR01283

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt