Version 5.4
Mus musculus Protein: Pla2g7
Summary
InnateDB Protein IDBP-184297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pla2g7
Protein Name phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Synonyms R75400;
Species Mus musculus
Ensembl Protein ENSMUSP00000024706
InnateDB Gene IDBG-184295 (Pla2g7)
Protein Structure
UniProt Annotation
Function Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
Subcellular Localization Secreted, extracellular space.
Disease Associations
Tissue Specificity Plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0005543 phospholipid binding
GO:0008236 serine-type peptidase activity
GO:0047499 calcium-independent phospholipase A2 activity
Biological Process
GO:0006508 proteolysis
GO:0006954 inflammatory response
GO:0016042 lipid catabolic process
GO:0034374 low-density lipoprotein particle remodeling
GO:0034440 lipid oxidation
GO:0034441 plasma lipoprotein particle oxidation
GO:0090026 positive regulation of monocyte chemotaxis
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0034362 low-density lipoprotein particle
Protein Structure and Domains
PDB ID MGI:1351327
InterPro IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR005065 Platelet-activating factor acetylhydrolase
IPR016715 Platelet-activating factor acetylhydrolase, eucaryote
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00326
PF03403
PRINTS
PIRSF PIRSF018169
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60963
PhosphoSite PhosphoSite-
TrEMBL Q9DB74
UniProt Splice Variant
Entrez Gene 27226
UniGene Mm.9277
RefSeq NP_038765
MGI ID
MGI Symbol Pla2g7
OMIM
CCDS CCDS28796
HPRD
IMGT
EMBL AK005158 AK051454 BC010726 CH466559 CT010585 U34277
GenPept AAC52274 AAH10726 BAB23849 BAC34647 CAQ11111 EDL23404 EDL23405 EDL23406

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca