InnateDB Protein
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IDBP-184311.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Khdc3
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Protein Name
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RIKEN cDNA 2410004A20 gene
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Synonyms
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2410004A20Rik; AI467128; FILIA; OEEP48;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000034737
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InnateDB Gene
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IDBG-606057 (Khdc3)
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Protein Structure
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Function |
Required for maintenance of euploidy during cleavage- stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA. {ECO:0000269PubMed:19376971, ECO:0000269PubMed:22276159}.
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Subcellular Localization |
Cytoplasm, cell cortex {ECO:0000269PubMed:18057100, ECO:0000269PubMed:18804437}. Note=Located throughout the cell cortex of ovulated eggs in a complex with NLRP5. After fertilization, restricted to the apical cortex and excluded from regions of cell-cell contact. {ECO:0000269PubMed:18057100}.
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Disease Associations |
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Tissue Specificity |
Detected in ovary, but not in testis or somatic tissues. In the ovary, expressed in growing oocytes. {ECO:0000269PubMed:18057100}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914241
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InterPro |
IPR004088
K Homology domain, type 1
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PFAM |
PF00013
PF13014
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CWU5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
G3UXW5
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UniProt Splice Variant |
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Entrez Gene |
66991
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UniGene |
Mm.489772
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RefSeq |
NP_080166
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MGI ID |
3V69
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MGI Symbol |
Khdc3
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OMIM |
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CCDS |
CCDS23336
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HPRD |
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IMGT |
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EMBL |
AB211060
AC157513
AK010377
AK021223
BC137808
BC137809
CH466522
DQ917421
DQ917422
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GenPept |
AAI37809
AAI37810
ABK91524
ABK91525
BAB26895
BAB32334
BAD95487
EDL26289
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