InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zmpste24

Summary

InnateDB Protein

IDBP-184354.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zmpste24

Protein Name

zinc metallopeptidase, STE24 homolog (S. cerevisiae)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053900

InnateDB Gene

IDBG-184352 (Zmpste24)

Protein Structure

UniProt Annotation

Function

Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. {ECO:0000269PubMed:11923874}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Nucleus inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0006998	nuclear envelope organization
GO:0030327	prenylated protein catabolic process
GO:0071586	CAAX-box protein processing

Cellular Component

GO:0005637	nuclear inner membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome