Version 5.4
Mus musculus Protein: Usp18
Summary
InnateDB Protein IDBP-184387.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usp18
Protein Name ubiquitin specific peptidase 18
Synonyms 1110058H21Rik; AW047653; Ubp15; UBP43;
Species Mus musculus
Ensembl Protein ENSMUSP00000032198
InnateDB Gene IDBG-184385 (Usp18)
Protein Structure
UniProt Annotation
Function Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 2 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019785 ISG15-specific protease activity
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0032020 ISG15-protein conjugation
GO:0035634 response to stilbenoid
Cellular Component
Protein Structure and Domains
PDB ID MGI:1344364
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
PFAM PF00443
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WTV6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 24110
UniGene Mm.326911
RefSeq NP_036039
MGI ID
MGI Symbol Usp18
OMIM
CCDS CCDS20489
HPRD
IMGT
EMBL AF069502 AK152034 AK152574 AK153312
GenPept AAD21222 BAE30893 BAE31326 BAE31893

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca