InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyth2

Summary

InnateDB Protein

IDBP-184403.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyth2

Protein Name

cytohesin 2

Synonyms

ARNO; CLM2; Pscd2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051423

InnateDB Gene

IDBG-184401 (Cyth2)

Protein Structure

UniProt Annotation

Function

Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. {ECO:0000269PubMed:18042453}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. Requires also interaction with phosphoinositides for targeting to plasma membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Present in all tissues tested, with highest protein levels in brain and adrenal.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0070679	inositol 1,4,5 trisphosphate binding