InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Unc13c

Summary

InnateDB Protein

IDBP-184406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc13c

Protein Name

unc-13 homolog C (C. elegans)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074726

InnateDB Gene

IDBG-184404 (Unc13c)

Protein Structure

UniProt Annotation

Function

May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses. {ECO:0000269PubMed:11150314}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized to presynaptic structures. {ECO:0000250}.

Disease Associations

Tissue Specificity

Restricted to cerebellum, predominantly in the granule cell layer. Almost exclusively present in the molecular layer in which the parallel fiber axons of granule cells terminate on dendrites of Purkinje neurons (at protein level). {ECO:0000269PubMed:11150314}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001566	non-kinase phorbol ester receptor activity
GO:0005515	protein binding
GO:0019992	diacylglycerol binding
GO:0046872	metal ion binding

Biological Process

GO:0006887	exocytosis
GO:0007268	synaptic transmission
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0030054	cell junction
GO:0042734	presynaptic membrane

Protein Structure and Domains

PDB ID

MGI:2149021

InterPro

IPR000008 C2 domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR010439 Calcium-dependent secretion activator
IPR019558 Mammalian uncoordinated homology 13, subgroup, domain 2

PFAM

PF00168
PF00130
PF06292
PF10540

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt