InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zswim2

Summary

InnateDB Protein

IDBP-184418.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zswim2

Protein Name

zinc finger, SWIM domain containing 2

Synonyms

1700025P14Rik; 4933437F18Rik; MEX;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044913

InnateDB Gene

IDBG-184416 (Zswim2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes. {ECO:0000269PubMed:16522193}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed only in testis. {ECO:0000269PubMed:16522193}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0043621	protein self-association
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006915	apoptotic process
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors