InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc6a13

Summary

InnateDB Protein

IDBP-184436.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc6a13

Protein Name

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

Synonyms

Gabt3; Gat2; GAT3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066779

InnateDB Gene

IDBG-184434 (Slc6a13)

Protein Structure

UniProt Annotation

Function

Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. In the liver, may be the major contributor for GABA uptake. Also involved in beta-alanine transport. {ECO:0000269PubMed:22896705}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:22896705}; Multi-pass membrane protein {ECO:0000269PubMed:22896705}. Note=In the kidney, detected at the basolateral membranes of parts of proximal tubules.

Disease Associations

Tissue Specificity

Expressed at high levels in liver, followed by kidney and leptomeninges, and very low levels in the cerebellum (at protein level).In the brain, detected in some blood vessels (at protein level). In the kidney, expressed in the cortex, including parts of the proximal tubules, but not in the medulla (at protein level). In the liver, highest expression in periportal hepatocytes, with highest density at the vascular side (at protein level). Also detected at low levels in other organs, including skeletal muscle. {ECO:0000269PubMed:22896705}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.