Version 5.4
Mus musculus Protein: Emb
Summary
InnateDB Protein IDBP-184499.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Emb
Protein Name embigin
Synonyms AL022799; Gp70;
Species Mus musculus
Ensembl Protein ENSMUSP00000022242
InnateDB Gene IDBG-184497 (Emb)
Protein Structure
UniProt Annotation
Function Plays a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. {ECO:0000250, ECO:0000269PubMed:19164284}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000269PubMed:19164284}. Note=Localizes to the neuromuscular junctions.
Disease Associations
Tissue Specificity Only member of the immunoglobulin superfamily to be expressed in embryonal carcinoma cells, which resemble multipotential cells of early embryos. {ECO:0000269PubMed:2963822}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0097159 organic cyclic compound binding
Biological Process
GO:0007155 cell adhesion
GO:0035879 plasma membrane lactate transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0030054 cell junction
GO:0045202 synapse
Protein Structure and Domains
PDB ID MGI:95321
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
PFAM PF07679
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P21995
PhosphoSite PhosphoSite-P21995
TrEMBL
UniProt Splice Variant
Entrez Gene 13723
UniGene Mm.397844
RefSeq NP_034460
MGI ID
MGI Symbol Emb
OMIM
CCDS CCDS26791
HPRD
IMGT
EMBL AK079570 AK088480 AK138271 AK148540 AK150625 AK166602 BC014858 J03535
GenPept AAA37730 AAH14858 BAC37687 BAC40381 BAE23603 BAE28610 BAE29715 BAE38887

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca